Molecular Biology, 3/e emphasizes the experimental data and results that support the concepts of molecular biology: DNA transcription, translation, replication, and repair. Experimental methods are extensively covered. The text presumes a prior course in general genetics.

Table of Contents

1 Introduction
1 A Brief History
2 The Molecular Nature of Genes
3 An Introduction to Gene Function
2 Methods of Molecular Biology
4 Molecular Cloning Methods
5 Molecular Tools for Studying Genes and Gene Activity
3 Transcription in Prokaryotes
6 The Mechanism of Transcription in Prokaryotes
7 Operons: Fine Control of Prokaryotic Transcription
8 Major Shifts in Prokaryotic Transcription
9 DNA-Protein Interactions in Prokaryotes
4 Transcription in Eukaryotes
10 Eukaryotic RNA Polymerases and Their Promoters
11 General Transcription Factors in Eukaryotes
12 Transcription Activators in Eukaryotes
13 Chromatin Structure and Its Effects on Transcription
5 Posttranscriptional Events
14 Messenger RNA Processing I: Splicing
15 Messenger RNA Processing II: Capping and Polyadenylation
16 Other RNA Processing Events
6 Translation
17 The Mechanism of Translation I: Initiation
18 The Mechanism of Translation II: Elongation and Termination
19 Ribosomes and Transfer RNA
7 DNA Replication, Recombination, and Transposition
20 DNA Replication I: Basic Mechanism and Enzymology
21 DNA Replication II: Detailed Mechanism
22 Homologous Recombination
23 Transposition
8 Genomes
24 Genomics and Proteomics

About the Author

Received BS in Chemistry from The College of Wooster in 1964 Postdoctoral work at UC-San Francisco with William Rutter American Cancer Society Research Scholar for two years