The Fourth Edition of this textbook teaches the artful science of the patient interview and the physical examination. Chapters are filled with clinical pearls, vignettes, step-by-step methods, and explanations of the physiologic significance of findings. New features include "Points to Remember", over 300 questions with answers and discussion, over 120 additional references, and expanded discussions of the usage and pitfalls of evidence-based medicine. Other highlights include expanded and updated discussions of sleep apnea, "minor" head trauma, cervical spine involvement in rheumatoid arthritis, transplantation-related problems, adverse effects of AIDS therapy, and more.