In 1919, Rachel Rabinowitz is a vivacious four-year-old living with her family in a crowded tenement on New York City’s Lower Eastside. When tragedy strikes, Rachel is separated from her brother Sam and sent to a Jewish orphanage where Dr. Mildred Solomon is conducting medical research. Subjected to X-ray treatments that leave her disfigured, Rachel suffers years of cruel harassment from the other orphans. But when she turns fifteen, she runs away to Colorado hoping to find the brother she lost and discovers a family she never knew she had.