Benjamin Franklin was the first to report the phenomenon of oil's power to still troubled waters and to speculate on why it happened. A century later Lord Rayleigh performed an identical experiment. Irving Langmuir did it with minor variations in 1917, and won a Nobel Prize for it. Then Langmuir's work was followed by a Dutch pediatrician's in 1925. ^p Each experimenter saw a little more in the result than his predecessor had seen, and the sciences of physics, chemistry and biology have all been illuminated by the work. ^p Charles Tanford reflects on the evolving nature of science and of individual scientists. Recounting innovations in each trial, he follows the classic experiment from Franklin's drawing room to our present-day institutionalized scientific establishments and speculates on the ensuing changes in our approach to scientific inquiry.