Fundamental change requires understanding a wide range of interests and accommodating change strategies accordingly. The challenges of transforming these ecosystems would easily qualify as "wicked problems"; social or cultural problems laced with incomplete or contradictory knowledge, large numbers of people and opinions, substantial economic burdens, and inextricable connections with other issues. Transforming Public-Private Ecosystems addresses these challenges for the four important ecosystems of national security, healthcare delivery, higher education, and energy and climate, and provides an integrated perspective for understanding and enabling change.