Carolyn James draws on unpublished correspondence between Isabella and Francesco over twenty-nine years, as well as their correspondence with relatives and courtiers, to show how their personal rapport evolved and how they cooperated in the governance of a princely state. Hitherto examined mainly from literary and religious perspectives, and on the basis of legal evidence and prescriptive literature, early modern marriage emerges here in vivid detail, offering the reader access to aspects of the lived experience of an elite Renaissance marital relationship. The study also contributes to our understanding of the history of emotions, of politics and military conflict, of childbirth, childhood and family life, and of the history of disease and medicine.