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Building and maintaining a mentoring network, practicing self-care and having a life outside of the lab, understanding that what works perfectly for a labmate might not work for you--these are just a few of the strategies that lab manager and molecular biologist Paris H. Grey and PI and geneticist David G. Oppenheimer wished they had implemented far sooner in their careers. They also offer practical advice on managing research projects, sharing your work on social media, and attending conferences. Above all, they coach early-career scientists to avoid burnout and make the most of every lab experience to grow and learn.