Ibuprofen: A Critical Bibliographic Review

Providing a comprehensive and critical review of the basic science and clinical aspects of the drug, this book covers the history and development of the drug and its current patterns of use and examines its basic pharmaceutical attributes and medicinal chemistry. The author discusses the properties of various formulations and discusses the pharmacokinetics of ibuprofen in animals and humans--highlighting the factors affecting absorption, distribution, metabolism, and elimination. Topics include: the clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions, the therapeutic uses in various acute and inflammatory conditions, and safety versus efficacy issues and the pharmacoepidemiological data.