Systemic lupus erythematosus (SLE) is a complex autoimmune condition characterized by various interacting susceptibility factors. Significant progress has been made in understanding the mechanisms that underlie its pathogenesis, as well as in identifying diagnostic markers. This advancement has led to the development of targeted therapies and alternative treatment options. The future management of SLE lies in molecular and personalized medicine, aiming to create high-quality treatments tailored to individual patients. This book on lupus offers a comprehensive analysis of the current status and future prospects of SLE diagnostics, along with recent developments in the field. Continued research and clinical studies are essential for discovering new diagnostic options and transforming the treatment approach for SLE. With sustained efforts and advancements in medical science, we can enhance the quality of life and improve survival rates for patients with this challenging condition.