The contributors explore how historical forces have changed regional associations and how regional associations have changed culture and history. The themes of culture, space, and institutions organize this volume: contributors historicize how race and racial thinking have evolved as a major force to define region and nation over time; the essays raise questions about the stability and validity of "canonical regions" in U.S. history to find new complexity in how these blocs form and how they understand themselves; and they focus on historicist and conjunctural trends and how institutions and ordinary people shape regional identities through politics and cultural change throughout history. Challenging ideas about both national belonging and local association, the contributors emphasize how regional analysis deepens understanding of migration, race, borders, infrastructure, climate, and Native sovereignty.