In the 21st century, the capitalist system has little more to offer than a menu of despair: pandemics, deepening inequality, worsening depression, out-of-control climate change, growing authoritarianism and intensifying militarism. This book offers a wide-ranging analysis of the origins, implications and scope of the "combined" crises of 2020 and beyond. It makes a compelling case that Karl Marx's critical analysis of capitalism, as well as his program of class-struggle socialism, are essential to understanding and addressing the most important social, economic, and ecological problems of our time.