This reprint aims to provide the reader with the latest clinical strategies and therapeutic innovations employed in managing asthma and allergies. This Special Issue seeks to unveil the potential and prospects of a multidisciplinary approach from traditional diagnostic methods to advanced functional monitoring techniques and the innovation of conventional and emerging therapies, including revolutionary monoclonal antibody-based biologic therapies. In this reprint, leading experts share their insights and cutting-edge visions for redefining the treatment of complex diseases, highlighting the path to increasingly personalized and effective management. Together, we will explore the synergies between diagnostic innovation and precision therapies, charting the path to a future in which patients' quality of life is enriched with new possibilities and increasingly refined therapeutic strategies.