This Special Issue focuses on the use of MRI in diagnosing and managing of prostate cancer. It is estimated that one in nine men will be diagnosed with prostate cancer in their lifetime, and magnetic resonance imaging (MRI) is a powerful imaging technique often used to diagnose and monitor prostate cancer. This Special Issue covers topics such as using MRI for prostate cancer screening and the role of MRI in the staging, prognosis, and treatment of prostate cancer. It also includes a review of the latest research and clinical applications of MRI-based radiomics in prostate cancer diagnosis. This Special Issue provides an invaluable resource for researchers, clinicians, and patients interested in the use of MRI for diagnosing and managing of prostate cancer.