Modern Immunosuppressives

Introduction, Global Perspectives and History of Immunosuppression.- Immunosuppressive Drugs.- Cyclosporine: Role of Pharmacokinetics.- Tacrolimus.- The Potential Role of Immunosuppressive Macrocyclic Lactones.- Inosine Monophosphate Dehydrogenase Inhibition: Mycophenolate Mofetil.- Biologicals.- Therapeutic Anti-T-cell Monoclonal Antibodies.- Targeting the IL-2 Receptor with Antibodies or Chimeric Toxins.- New Avenues in Immunosuppression.- Emerging Therapeutic Strategies for the Prevention and Treatment of Chronic Allograft Rejection.- Tolerance Induction.- Gene Therapy Approaches to Immunosuppression.- Perspectives.- A rigorous approach to the diagnosis of synergy among combination therapies of immunosuppressive agents.- Lessons for transplantation of cyclosporine experience in the treatment of autoimmune diseases.