B cell targets in rheumatoid arthritis.- Co-stimulatory pathways in the therapy of rheumatoid arthritis.- Immunobiology of IL-6 - Tocilizumab (Humanized anti-IL-6 receptor antibody ) for the treatment of RA.- Role of IL-1 in erosive arthritis, lessons from animal models.- Interleukin-15.- IL-17 and Th17 cells, key players in arthritis.- Role of il-18 in inflammatory diseases.- Chemokines and chemokine receptors.- Signaling pathways in rheumatoid arthritis.- Targeting oncostatin M in the treatment of rheumatoid arthritis.- Targeting the epigenetic modifications of synovial cells.- Perspectives in targeted therapy.