This monograph includes the latest modern data on coronary heart disease, the peculiarity of its course, etiopathogenetic risk factors predisposing to the development or progression of this disease, especially in men of working age. The literary review was compiled on the basis of modern literary sources from the CIS countries and foreign countries. When analyzing the literature, the authors were able to identify several predisposition factors for the development of coronary heart disease in working-age men, including dyslipidemia and cytokine imbalance. Based on our own clinical, laboratory, and immunological studies, we describe the characteristics of the clinical course and treatment strategies for coronary heart disease in working-age men, depending on etiopathogenetic risk factors.