This systematic review explores the effectiveness of eugenol versus non-eugenol periodontal dressings in promoting healing after periodontal surgeries. Eugenol dressings offer antimicrobial and analgesic benefits but may cause irritation or allergic reactions, while non-eugenol dressings like Coe-Pak are safer, more comfortable, and widely accepted. Analyzing data from 15 clinical studies, the review highlights that non-eugenol dressings generally provide better patient comfort with fewer side effects, though the choice of dressing should be individualized based on patient needs and surgical context. This evidence-based work is a valuable guide for clinicians aiming to enhance post-surgical outcomes in periodontics.