Tens of thousands of natural products have been identified from plants and hundreds of thousands are yet to be isolated and screened for their bioactivities. This large reservoir of organic chemicals is largely untapped or under-tapped for use as pesticides. In this chapter the traditional applications of native plants as pesticidal agents and the results of biological and chemical studies on these plants in the past few decades are examined with a view to assessing their potential use in agriculture and related fields. The factors influencing efficacy, the advantages of and problems associated with the use of plant-based pesticidal products are also discussed. The pesticidal agents that will be dealt with will include insecticides (insect killers including adults, ova, and larvae) insect repellents, antifeedants, molluscicides, fungicides and phytotoxins (herbicides). It must however be stated at this stage that although much work has been done in the past decades to show that indeed plants have the potentials to provide alternative and safe pesticides to replace the synthetic ones not enough work has been done in the area of identifying the active components.