Covering both IPv4 and IPv6, this book details the internal workings of IP fragmentation and reassembly, the function and limitations of Path MTU Discovery (PMTUD), and the role of protocols like TCP, UDP, ICMP, and QUIC in adapting to MTU constraints. It addresses real-world challenges such as black hole routers, firewall interference, VPN and tunnel encapsulation overhead, mobile and IoT constraints, and how to diagnose MTU mismatches using practical tools and methods. Readers will gain the skills needed to prevent silent packet drops, improve data throughput, and ensure robust connectivity across hybrid cloud, SD-WAN, wireless, and virtualized infrastructures. With forward-looking chapters on emerging trends and automation strategies, including software-defined networking, application-aware MTU handling, and observability frameworks, this book equips professionals with the knowledge to build resilient, future-ready networks. Whether designing high-performance data centers, managing edge deployments, or securing cross-domain communication, this resource provides the expertise necessary to master MTU and fragmentation in the evolving digital landscape.