Frank has questions, many questions.
Startled to learn that his wife did not die after smoking mushrooms, in their mushroom smoker and burning the house down, Frank sets off on a quest to find her, and the many answers to the many questions that he has about her disappearance.
The quests just keep coming, as there's trouble in paradise, a rogue saint, Saint Charlie, has quit his job as a saint, and he's come to Earth to make the world his domain.
Frank must battle the rouge Saint Charlie, find his wife, save everyone because everyone except him seems to be rubbish at not needing saving, but he cant do it alone, Frank must find help, and as everyone but him on Earth appears to be rubbish at this sort of caper, he must look, somewhere else.